For Road & Gravel applications (with a dropbar):
No. The transmitter module is only compatible with Shimano Di2-spec handlebars with a hole for the wiring positioned near the end of the handlebar.
These are handlebars such as Pro Vibe alloy and Pro Vibe carbon.
Do not drill holes in your handlebars. This will void the warranty and can lead to injury or death.
For MTB applications (with a flat bar): Compatible with 22mm diameter flat bars.